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The cottontail rabbit papilloma virus (CRPV), or Shope papilloma virus (also known as Kappapapillomavirus 2, Cottontail rabbit papillomavirus, and Rabbit (Shope) papilloma virus), is a type I virus under the Baltimore scheme, possessing a nonsegmented dsDNA genome.〔("Cottontail rabbit papillomavirus" ) in UniProt〕 The virus was originally separated from horny warts on cottontail rabbits by Richard E. Shope in 1933. It infects rabbits, causing keratinous carcinomas, typically on or near the animal’s head. These tumors can become large enough that they interfere with the host’s ability to eat, eventually causing starvation. Shope papilloma virus provided the first mammalian model of a cancer caused by a virus. It takes its name from Shope, who discovered it in the 1930s. Shope was able to isolate virus particles from tumors on captured animals and use these to inoculate domestic rabbits, which then developed similar tumors.〔http://www.ratsteachmicro.com/2003_HCOE_PDFs/Papovavirus_Lecture_Outline__2005rev.pdf〕 The virus was sequenced in 1984, showing substantial sequence similarities to HPV1a. It has been used as a model for human papillomaviruses both before and after this discovery. The most visible example of this role is the HPV vaccine, which was developed based on and incorporating research done using the virus as a model. Similarly, it has been used to investigate antiviral therapies. The virus is also a possible source of myths about the jackalope, a rabbit with the horns of an antelope, and related cryptids such as the wolpertinger.〔Eberhart, George M. "Mysterious Creatures: Creating A Cryptozoological Encyclopedia." 2005. Journal of Scientific Exploration. Vol. 19, No. 1, pp. 103-113〕 Stories and illustrations of horned rabbits appear in scientific treatises dating back many years, such as the ''Tableau encyclopédique et méthodique'', from 1789.〔("Cottontail rabbit papillomavirus was the first mammalian papillomavirus to be discovered" )〕 ==See also== Oncovirus (cancer virus) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Shope papilloma virus」の詳細全文を読む スポンサード リンク
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